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Rabbit anti-rat cytochrome P450 enzyme CYP2D1 (polyclonal antibody). O-demethylation of xenobiotics, CYP2D6 is involved in the metabolism and elimination of approximately 25% of clinically used drugs in humans1. Primarily expressed in the liver and areas of the CNS. CYP2D1 and CYP2D4 have a similar function in rats2.

CODE NUMBER: RK05.

QUANTITY: 0.1 mL.

SPECIFICITY: Reacts with rat cytochrome P450 enzyme CYP2D1 in hepatic microsomal fraction.

IMMUNOGEN: Synthetic peptide.

SUGGESTED APPLICATIONS: Western blot, immunohistochemistry on frozen and formaldehyde treated sections. Optimal working dilutions must be determined by end user.

SPECIES REACTIVITY: Rat.

FORMAT: Rabbit antiserum.

PRESENTATION: Liquid. No preservatives.

STORAGE/HANDLING: Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

For research use only; not for use in diagnostic procedures. Not for human or animal consumption.

CYP2D1 is also known as CYPIID1, Cyp2d-1, Cyp2d9 and Cytochrome P450-CMF1A

 

To purchase this antibody, please email quicktech@imperialinnovations.co.uk

 

Antibodies specific to the following related cytochrome P450 species are also available:

 

 

1. Wang et al. (2009) New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme, Drug Metabolism Reviews 41(4):573-643

2. Martagnoni et al. (2006) Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction, Expert Opinion on Drug Metabolism & Toxicology 2(6): 875-894

 

Internal case number: 1612

Polyclonal antibody for rat cytochrome P450 enzyme CYP2D1

Specific to rat cytochrome P450 enzyme CYP2D1, raised in rabbits

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General POA Licence 0.10

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Term: perpetual (does not require renewal)
Seats: n/a

Price excl. VAT: P.O.A. (price on application)

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