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The team isolated a novel IgG autoantibody, IgG3k (designated Mab LO1), that reacts with oxidized LDL.LO1 reacts with copper-oxidized LDL (Cu-OxLDL) and in vitro with malondialdehyde-conjugated LDL (MDA-LDL), which is known to be a prominent epitope in copper-oxidized LDL preparations

The immunoglobulin variable regions of the heavy and light chains of LO1 were sequenced found to be 99% germline.

No reactivity with other forms of modified LDL tested, such as by trypsin digestion or incubation with hypochlorite.

Applications: Detection of human, rabbit or mouse oxidized LDL. Oxidized LDL from other species has not been tested.

  • In vivo by near infra-red fluorescence (NIRF)
  • imaging in tissue sections by immunohistochemisty
  • in vitro by ELISA.

Atherosclerosis - increasing evidence implicates IgG autoantibodies against oxidized forms of low density lipoprotein (oxLDL) in the pathophysiology of atherosclerotic arterial disease.

 

Internal case number: 5873

Antibody against oxidized Low Density Lipoprotein (OxLDL)

IgG monoclonal Ab against oxidized LDL, derived from splenocytes extracted from an LDL receptor-deficient mouse

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General POA Licence 0.20

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