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Rabbit anti-human cytochrome P450 enzyme CYP3A4 (polyclonal antibody). Heme-thiolate monooxygenase, involved in metabolism of several steroids, fatty acids, and xenobiotics. CYP3A4 & 5 are the two most predominant proteins within the CYP3A subfamily in human adults, which are collectively involved with the biotransformation of 50% of oxidatively metabolised drugs1

CODE NUMBER: R2X.

QUANTITY: 0.1 mL.

SPECIFICITY:  Reacts with human cytochrome P450 enzyme CYP3A4 in hepatic microsomal

fraction from adult donors. Also binds to the fetal form: CYP3A7. No cross-reactivity with CYP3A5.

IMMUNOGEN:  Synthetic peptide.

SUGGESTED APPLICATIONS:  Western blot, immunohistochemistry on frozen and formaldehyde treated sections. Optimal working dilutions must be determined by end user.

SPECIES REACTIVITY:  Human.

FORMAT:  Rabbit antiserum.

PRESENTATION:  Liquid. No preservatives.

STORAGE/HANDLING:  Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

For research use only; not for use in diagnostic procedures. Not for human or animal consumption.

 

CYP3A4 is also known as CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3 and P450PCN1

 

 

To purchase this antibody, please contact quicktech@imperialinnovations.co.uk

 

 

Antibodies specific to the following related cytochrome P450 species are also available:

 

 

1. Williams et al. (2002) Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7, Drug Metabolism and Disposition 30(8): 883-91

 

Internal case number: 1612

Polyclonal antibody for human cytochrome P450 enzyme CYP3A4

Specific to human cytochrome P450 enzyme CYP3A4, raised in rabbits

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General POA Licence 0.10

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Further details
Term: perpetual (does not require renewal)
Seats: n/a

Price excl. VAT: P.O.A. (price on application)

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