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We have available a library of CYP450 (cytochrome P450) antibodies, reactive against a range of CYP450 enzymes in humans and rats.

These antibodies were raised in rabbits (polyclonal) and are available in 1mL vials of serum. They have been supplied to researchers for a number of years.

Please click on the code number to select a particular antibody.

ENZYME TARGET

CODE

FURTHER DESCRIPTION/SPECIFICITY

SPECIES REACTIVITY

CYP1A1 (Human)

R3H

Reacts with human cytochrome P450 enzyme CYP1A1 in placental microsomal fraction. No cross-reactivity with other cytochrome P450 enzymes including CYP1A2

Human

CYP1A1 (Rat)

R2U

Reacts with rat cytochrome P450 enzyme CYP1A1 in hepatic microsomal fraction. No cross-reactivity with other cytochrome P450 enzymes including CYP1A2 Rat
CYP1A1 and CYP1A2 (Rat) R1V Reacts with rat cytochrome P450 enzymes CYP1A1 and CYP1A2 in hepatic microsomal fraction. No cross-reactivity with other cytochrome P450 enzymes Rat
CYP1A2 (Human) R2Q Reacts with human cytochrome P450 enzyme CYP1A2 in hepatic microsomal fraction. No cross-reactivity with other cytochrome P450 enzymes including CYP1A1 Human
CYP2C8/9/19 (Human) and CYP2C12 (Rat) RK03 Reacts with cytochrome P450 CYP2C8, CYP2C9 and CYP2C19 in human hepatic microsomal fraction and to CYP2C12 in rat hepatic microsomal fraction Human and Rat
CYP2D1 (Rat)

RK05

Rabbit anti-rat cytochrome P450 enzyme CYP2D1 (polyclonal antibody) Rat
CYP2D4 (Rat)

R3P

By immunohistochemistry the antibody reveals strong staining in rat brain, but not liver, consistent with CYP2D4 Rat
CYP2D6 (Rat) RT01 Reacts with human cytochrome P450 enzyme CYP2D6 in hepatic microsomal fraction. No cross-reactivity with other cytochrome P450 enzymes Rat
CYP2E1 (Human and Rat)

R2V

Reacts with human and rat cytochrome P450 enzyme CYP2E1 in hepatic microsomal fraction. No cross-reactivity with other cytochrome P450 enzymes in these species Human and Rat
CYP3A1 (Rat) RK07 Reacts with rat cytochrome P450 enzyme CYP3A1 in hepatic microsomal fraction. No cross-reactivity with other cytochrome P450 enzymes including CYP3A2 Rat
CYP3A2 (Rat) RK08 Binds specifically to cytochrome P450 CYP3A2 in rat hepatic microsomal fraction. No cross-reactivity with other cytochrome P450 enzymes including CYP3A1 Rat
CYP3A4 (Human) R2X Reacts with human cytochrome P450 enzyme CYP3A4 in hepatic microsomal fraction from adult donors. Also binds to the fetal form: CYP3A7. No cross-reactivity with CYP3A5 Human
CYP3A5 (Human) R3M Reacts with human cytochrome P450 enzyme CYP3A5 in hepatic microsomal fraction. No cross-reactivity with other cytochrome P450 enzymes including CYP3A4 Human
CYP4A1, CYP4A2 and CYP4A3 (Rat) RK09 Binds specifically to cytochrome P450 enzymes CYP4A1, CYP4A2 and CYP4A3 in rat hepatic microsomal fraction Rat

 

In all cases:

IMMUNOGEN:  Synthetic peptide.

FORMAT:  Rabbit antiserum.

PRESENTATION:  Liquid. No preservatives.

STORAGE/HANDLING:  Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

SUGGESTED APPLICATIONS:  Western blot, immunohistochemistry on frozen and formaldehyde treated sections. Optimal working dilutions must be determined by end user.

 

Internal case number 1612

cytochrome P450 polyclonal Antibodies

Portfolio of Polyclonal antibodies for cytochrome P450 enzymes in rat and humans

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