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Cell lines are invaluable tools for biomedical research. Cancer cell lines are the foundation of cancer biology and the quest for drug treatments. Adenocarcinoma is a cancer of the epithelium (including colon) and originates in glandular tissue, such as skin surface layer and glands.

Please email quicktech@imperialinnovations.co.uk to discuss the release of these supplies.

 

Product

These human adenocarcinoma cell lines have been previously licensed to commercial parties for research into human adenocarcinoma treatments.

These cell lines are available through Public Health England ECACC. Please make your purchase through the links below.

Imperial Innovations requests that commercial/for profit parties contact them first to discuss the terms of supply prior to Innovations authorising the release of supplies from ECACC.

HRA-19a1.1 alpha2alpha1 cells are HRA-19a1.1 cells transfected with a plasmid contruct expressing alpha2 integin and the extracellular and transmembrane region of alpha1 integrin. In experiments, this cell line showed a significantly suppressed endrocrine and mucous cell lineage commitment relative to the parent cell line.

 

Data from: S C Kirkland and H Ying (2008) α2β1 Integrin regulates lineage commitment in multipotent human colorectal cancer cells, J Biol Chem, 283(41): 27612-27619

 

 

The following cell lines are available:

The parent cell line, HRA-19a1.1 and wild-type alpha 2 integrin expressing cell lines seen above are also available:

 

Other similar cell lines are also available:

Target market

Industrial or academic R&D groups working in adenocarcinoma drug development.

 

Internal case number: 5129

Human rectal adenocarcinoma HRA-19a1.1 alpha2alpha1 B

Expresses construct with alpha2 and alpha1 integrin domains. Displays suppressed endocrine and mucous lineage commitment

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