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Rhinoviruses cause the common cold, acute exacerbations of asthma and other serious respiratory diseases such as chronic obstructive pulmonary disease.

The major group (MG) of rhinovirus serotypes use the human receptor ICAM-1 for cell attachment and entry and do not bind in murine ICAM-1, thus making such disease models unsuitable for the study of rhinovirus-related diseases.

Researchers at Imperial College London have developed a BALB/c strain transgenic disease model for the rhinovirus-binding extracellular domains 1 and 2 of human ICAM-1. As described in the Nature Medicine publication MG rhinovirus-infected transgenic BALB/c develop many of the disease-related outcomes seen in human rhinovirus infections including:

  • airway neutrophilic and lymphocytic inflammation
  • mucin secretion
  • induction of various chemokines and proinflammatory cytokines
  • production of virus-specific antibodies

The ICAM-1 disease model can be used to study rhinovirus related diseases and is available for non-exclusive licence.

This product does not yet have a pre-set licence agreement attached it. To discuss licensing the product, please contact: Gursharan Randhawa

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Internal case number: 2808

 

 

Mouse model expressing human ICAM-1

Disease model for Rhinoviruses

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ICAM (pre-license) 0.10

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Term: 12 months
Seats: n/a

Price excl. VAT: P.O.A. (price on application)

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