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Photomicrograph of immune cells (macrophages) infected with the causative agent of tuberculosis (TB), Mycobacterium tuberculosis (stained red) (magnification x1000).

Image A shows infection with wild-type M. tuberculosis, which is able to 'hide' in immune cells, allowing them to survive for longer.

Image B depicts infection with a mutant form of M. tuberculosis. The cells are highly activated becasue the immune evasion mechanisms of the wild-type M. tuberculosis are not present, so the cells are able to mount a stronger immune response.

Understanding how M. tuberculosis modulates the immune system could help us to discover new ways to treat TB.

 

Image is sold on behalf of providing scientist. Internal case number: 7951 

Tuberculosis-infected macrophages

Comparison of macrophages infected with wild-type TB and a mutant strain with compromised immune evasion capability

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