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Rabbit anti-human cytochrome P450 enzyme CYP3A4 (polyclonal antibody). Heme-thiolate monooxygenase, involved in metabolism of several steroids, fatty acids, and xenobiotics. CYP3A4 & 5 are the two most predominant proteins within the CYP3A subfamily in human adults, which are collectively involved with the biotransformation of 50% of oxidatively metabolised drugs1



SPECIFICITY:  Reacts with human cytochrome P450 enzyme CYP3A4 in hepatic microsomal

fraction from adult donors. Also binds to the fetal form: CYP3A7. No cross-reactivity with CYP3A5.

IMMUNOGEN:  Synthetic peptide.

SUGGESTED APPLICATIONS:  Western blot, immunohistochemistry on frozen and formaldehyde treated sections. Optimal working dilutions must be determined by end user.


FORMAT:  Rabbit antiserum.

PRESENTATION:  Liquid. No preservatives.

STORAGE/HANDLING:  Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

For research use only; not for use in diagnostic procedures. Not for human or animal consumption.


CYP3A4 is also known as CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3 and P450PCN1



To purchase this antibody, please contact quicktech@imperialinnovations.co.uk



Antibodies specific to the following related cytochrome P450 species are also available:



1. Williams et al. (2002) Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7, Drug Metabolism and Disposition 30(8): 883-91


Internal case number: 1612

Polyclonal antibody for human cytochrome P450 enzyme CYP3A4

Specific to human cytochrome P450 enzyme CYP3A4, raised in rabbits

Please check carefully that the terms you select correspond to your intended use of the product.

General POA Licence 0.10

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Further details
Term: perpetual (does not require renewal)
Seats: n/a

Price excl. VAT: P.O.A. (price on application)

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