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A full list of 25 novel isoindolinones developed at Imperial can be downloaded from the 'Files' tab above.


JoC code: E-2db

Formula: C17H14ClNO2

Novel isoindolinone developed via tandem process involving Pd-catalysed Fujiwara−Moritani−aza-Wacker reactions.

3-Benzyl-substituted-isodolinones are a family of pharmacores of significant interest in therapeutic use. Molecules from this family have previously been patented by pharamceutical companies for use as glycine transporter (GlyT1) and aldosterone synthase (CYP11B2 or CYP11B1) inhibitors.

In addition, many natural products known to have anti-tumour properties comprise a similar substructure, including isoindolobenzazepine alkaloids (e.g., lennoxamine, chileamine) and aristolactam alkaloids
(e.g piperolactams).




Information on the synthesis of these compounds can be found in DOI: 10.1021/acs.joc.6b01696.



Internal case number: 8095


Novel isoindolinone developed from N-methoxy benzamide (JoC code E-2db)

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